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Chiral selection in poly(C)-directed synthesis of oligo(G)An experimental study is reported which shows that poly(C)-directed oligomerization of activated guanosine mononucleotides proceeds readily if the monomers are of the same optical handedness as the template, and is far less efficient if the monomers are of the opposite handedness. However, in template-directed reactions with a racemic mixture, monomers of the opposite handedness to the template are incorporated as chain terminators at the 2'(3') end of the products. This inhibition raises an important problem for many theories of the origin of life.
Document ID
19840062332
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Joyce, G. F.
(Salk Inst. for Biological Studies San Diego, CA, United States)
Orgel, L. E.
(Salk Institute for Biological Studies San Diego, CA, United States)
Visser, G. M.
(Salk Inst. for Biological Studies San Diego, CA, United States)
Van Boom, J. H.
(Salk Inst. for Biological Studies San Diego, CA, United States)
Van Westrenen, J.
(Leiden Rijksuniversiteit, Leiden, Netherlands)
Van Boeckel, C. A. A.
(Organon International Oss, Netherlands)
Date Acquired
August 12, 2013
Publication Date
August 16, 1984
Publication Information
Publication: Nature
Volume: 310
ISSN: 0028-0836
Subject Category
Space Biology
Report/Patent Number
ISSN: 0028-0836
Accession Number
84A45119
Distribution Limits
Public
Copyright
Other

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