NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Actual and Simulated Weightlessness Inhibit Osteogenesis in Long Bone Metaphysis by Different MechanismsWeightlessness and simulated weightlessness inhibit the rate of periosteal bone formation in long bones. Formation of preosteoblasts is suppressed in periodontal ligament (PDL) of maxillary molars, which suggests a generalized block in osteoblast histogenesis. Growth in length of long bones is decreased by simulated weightlessness, but there are no reliable data on the influence of actual weightlessness on metaphyseal growth. The nuclear size assay for assessing relative numbers of osteoblast precursor cells was utilized in the primary spongiosa of growing long bones subjected to actual and simulated weightlessness. It is found that: (1) Actual weightlessness decreases total number of osteogenic cells and inhibits differentiation of osteoblast precursor cells, (2) Simulated weightlessness suppresses only osteoblast differentation; and (3) The nuclear morphometric assay is an effective means of assessing osteogenic activity in the growing metaphysis or long bones.
Document ID
19850017763
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Roberts, W. E.
(University of the Pacific San Francisco, CA, United States)
Date Acquired
August 12, 2013
Publication Date
April 1, 1985
Publication Information
Publication: NASA. Washington NASA Space Biol. Program:
Subject Category
Life Sciences (General)
Accession Number
85N26074
Funding Number(s)
CONTRACT_GRANT: NAGW-356
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
Document Inquiry

Available Downloads

There are no available downloads for this record.
No Preview Available