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Simulated Microgravity as a Probe for Understanding the Mechanisms of Early Pattern SpecificationEarly pattern specification (e.g., axial structure morphogenesis, doreal ventral polarity, etc.) is monitored in amphibian eggs which were subjected to microgravity simulation by constant rotation on a horizontal clinostat. In contrast to previous clinostat experiments, rotation is initiated either prior to fertilization or immediately thereafter. Large proportions of clinostated eggs developed normal axial structures. A model which employs a multiple set of signals for specifying early pattern is discussed. Effects of microgravity simulation on the earliest post fertilization pattern specification event dorsal/ventral polarization is analyzed in detail. Other models are developed and they are discussed. As a general mechanism for explaining the manner in which regional developmental patterns emerge from the initial, radially symmetrial egg, the density compartment model is described. The identification of the various zones or compartments of egg cytoplasm using inverted eggs is explained.
Document ID
19850017781
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Neff, A. W.
(Indiana Univ. Bloomington, IN, United States)
Malacinski, G. M.
(Indiana Univ. Bloomington, IN, United States)
Date Acquired
August 12, 2013
Publication Date
April 1, 1985
Publication Information
Publication: NASA. Washington NASA Space Biol. Program:
Subject Category
Life Sciences (General)
Accession Number
85N26092
Funding Number(s)
CONTRACT_GRANT: NAGW-60
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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