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Percutaneous connectorsA surface possessing a regular array of micro-pillars was evaluated with regard to its ability to control epithelial downgrowth at the percutaneous interface. A range of pillar sizes were applied to the vertical segment of T shaped Biomer (R) implants. These percutaneous tabs were implanted into the dorsum of cats for a period of 6 weeks using a standardized surgical technique. Comments were made post-operatively and at the time of retrieval. A quantitative scoring system was applied to these observations as well as histological results. As observed, the pillar morphology used displayed the ability to control epithelial downgrowth. Collagen ingrowth into the interpillar spaces and possibly direct interactions of the epithelial cells with the morphology may account for the inhibition. The reproducibility of epithelial inhibition is, however, limited by other factors which are currently not well understood. These factors and potential methods of assessment are discussed.
Document ID
19850019197
Acquisition Source
Legacy CDMS
Document Type
Contractor Report (CR)
Authors
Picha, G. J.
(Applied Medical Technology, Inc. Brecksville, OH, United States)
Taylor, S. R.
(Applied Medical Technology, Inc. Brecksville, OH, United States)
Date Acquired
September 5, 2013
Publication Date
September 1, 1981
Subject Category
Life Sciences (General)
Report/Patent Number
NASA-CR-175627
AR-1
NAS 1.26:175627
Report Number: NASA-CR-175627
Report Number: AR-1
Report Number: NAS 1.26:175627
Accession Number
85N27508
Funding Number(s)
CONTRACT_GRANT: NAS3-22654
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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