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Recovery of the vomiting reflex following area postrema ablation in squirrel monkeysThe role of the area postrema (AP) in motion-induced emesis was re-assessed recently in several different species. In a few of these studies, the role of the AP in motion-induced conditioned taste aversion (CTA) was also addressed. The purpose was to extend this comparative study to the squirrel monkey, to evaluate further the role of AP in vomiting, and to investigate the dynamics of the recovery process. The AP was ablated bilaterally in 7 motion-susceptible squirrel monkeys which previously had been characterized in terms of their responses to various motion sickness-inducing stimuli. After recovery from surgery all animals were tested at 30-day intervals for a period of 11 months to determine the effects of AP ablations on susceptibility to the same sickness-inducing conditions. In addition, the effectiveness of motion in preducing CTA was evaluated. All pre-ablation motion tests involved stimulation for 30 min., while post-lesion tests were 60 min., in duration. All animals showed significant increases in latencies to vomiting after AP ablations. However, the latencies tended to decrease with time after ablation. All but one animal vomited on at least one of the 10 motion tests occurring after ablation of AP. In addition, CTA was produced by motion used in the conditioning sessions. These results suggest that structures other than AP, and processes other that those mediated through AP, may play an important role in motion-induced emesis.
Document ID
Document Type
Reprint (Version printed in journal)
Elfar, S.
(NASA Ames Research Center Moffett Field, CA, United States)
Brizzee, Kenneth R.
(Tulane Univ. Covington, LA., United States)
Fox, Robert A.
(San Jose State Univ. CA., United States)
Corcoran, Meryl Lee
(NASA Ames Research Center Moffett Field, CA, United States)
Daunton, Nancy G.
(NASA Ames Research Center Moffett Field, CA, United States)
Coleman, J.
(San Jose State Univ. CA., United States)
Date Acquired
September 6, 2013
Publication Date
January 1, 1991
Publication Information
Publication: Self-Motion Perception and Motion Sickness
Subject Category
Life Sciences (General)
Accession Number
Distribution Limits
Work of the US Gov. Public Use Permitted.
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