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Area postrema ablations in cats: Evidence for separate neural routes for motion- and xylazine-induced CTA and emesisPrevious studies on the role of the area postrema (AP) in vomiting induced in the cat by motion and drugs have shown that the AP is not essential for motion-induced vomiting, but is necessary for vomiting to apomorphine and xylazine. To confirm these findings and to determine the role of the AP in the formation of Conditioned Taste Aversion (CTA), the AP was ablated bilaterally in 10 adult female cats. With one exception, the ablated cats continued to vomit to the same motion that elicited emesis before the ablation. Doses of xylazine and apomorphine that elicit emesis in intact cats, failed to induce emesis in the ablated cats. Histological examination indicated that 8 cats had complete lesions and 2 had partial lesions. Investigations of effects of AP ablations on CTA revealed that cats with complete lesions did not form CTA to flavored milk paired with xylazine-induced CTA. Seven of the eigth completely lesioned cats developed motion-induced CTA, even though emesis was not consistently elicited by motion. These results suggest that there are multiple routes for inducing CTA and the emetic reflex, that CTA can form without eliciting emesis, and that CTA may be a sensitive measure of sub-emetic motion sickness.
Document ID
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Corcoran, Meryl Lee
(NASA Ames Research Center Moffett Field, CA, United States)
Fox, Robert A.
(San Jose State Univ. CA., United States)
Brizzee, Kenneth R.
(Tulane Univ. Covington, LA., United States)
Crampton, G.
(Wright State Univ. Dayton, OH., United States)
Daunton, Nancy G.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
September 6, 2013
Publication Date
January 1, 1991
Publication Information
Publication: Self-Motion Perception and Motion Sickness
Subject Category
Life Sciences (General)
Accession Number
Distribution Limits
Work of the US Gov. Public Use Permitted.

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