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Experimental studies of gastric dysfunction in motion sickness: The effect of gastric and vestibular stimulation on the vagal and splanchnic gastric efferentsThe experiments were conducted in anaesthetized rats. In the first part of the experiments, the effect of CuSO4 on the afferent activity in the gastric branch of the vagus nerve was investigated. Gastric perfusion of CuSO4 solution (0.04 percent and 0.08 percent) provoked an increase in afferent activity. In the second part of the experiments, the reflex effects of gastric perfusion of CuSO4 solution, repetitive stimulation of the gastric vagus nerve, and caloric stimulation of the right vestibular apparatus (5-18 C water) on gastric autonomic outflow were investigated. The results of these experiments showed that these three different types of stimulation caused an inhibition in efferent activity of the gastric vagus nerve and a slight activation of the splanchnic gastric efferents. The summation of the effect of each stimulation was also observed. These results, therefore, provide evidence for a possible integrative inhibitory function of the vagal gastric center as well as an excitatory function of gastric sympathetic motoneurons in relation to motion sickness.
Document ID
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Niijima, A.
(Niigata Univ. Japan)
Jiang, Z. Y.
(Niigata Univ. Japan)
Daunton, Nancy G.
(NASA Ames Research Center Moffett Field, CA, United States)
Fox, Robert A.
(San Jose State Univ. CA., United States)
Date Acquired
September 6, 2013
Publication Date
January 1, 1991
Publication Information
Publication: Self-Motion Perception and Motion Sickness
Subject Category
Life Sciences (General)
Accession Number
Distribution Limits
Work of the US Gov. Public Use Permitted.
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