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Neoplastic transformation of human cellsThe goal of this project was to gain a better understanding of the cellular mechanisms of cancer induction by ionizing radiation as a risk assessment for workers subjected to high LET irradiation such as that found in space. The following ions were used for irradiation: Iron, Argon, Neon, and Lanthanum. Two tests were performed: growth in low serum and growth in agar were used as indicators of cell transformation. The specific aims of this project were to: (1) compare the effectiveness of various ions on degree of transformation of a single dose of the same RBE; (2) determine if successive irradiations with the same ion (Ge 600 MeV/u) increases the degree of transformation; (3) test if clones with the greatest degree of transformation produce tumors in nude mice; and (4) construct a cell hybrid of a transformed and control (non-transformed) clone. The cells used for this work are human mammary epithelial cells with an extended lifespan and selected for growth in MEM + 10% serum.
Document ID
19960001020
Acquisition Source
Legacy CDMS
Document Type
Contractor Report (CR)
Authors
Goth-Goldstein, Regine
(California Univ. Berkeley. Lawrence Berkeley Lab, CA, United States)
Date Acquired
September 6, 2013
Publication Date
July 31, 1995
Subject Category
Aerospace Medicine
Report/Patent Number
NASA-CR-199483
NAS 1.26:199483
Report Number: NASA-CR-199483
Report Number: NAS 1.26:199483
Accession Number
96N11020
Funding Number(s)
CONTRACT_GRANT: NASA ORDER T-9297-R
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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