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Mechanisms of Bone Mineralization and Effects of Mechanical LoadingThe data suggest that PTH and PKC inhibit nodule formation, and that alternative energy sources are utilized by osteoblasts in the process of mineralization. The conditions and techniques to grow, fix, photograph, and measure bone mineralization in vitro were defined. The results are presently in preliminary form and require further assessment as follows; quantitate the surface area of nodules + treatments via computer-aided image analysis; use PTH + inhibitors of signaling pathways to determine the mechanism of nodule formation; determine how protein kinase C is involved as a promotor of nodule formation; cell proliferation vs. cell death affected by modulation of signal transduction (i.e., PTH, enzyme inhibitors and activators); identify mRNA induced or decreased in response to PTH and signaling modulators that encode proteins that regulate cell morphology, proliferation, and nodule formation. Therefore, several follow-up studies between the laboratories at NASA-Ames Research Center and my laboratory at the University of Illinois have been initiated.
Document ID
Document Type
Babich, Michael (Illinois Univ. Rockford, IL United States)
Date Acquired
August 17, 2013
Publication Date
October 1, 1996
Subject Category
Aerospace Medicine
Distribution Limits
Work of the US Gov. Public Use Permitted.

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IDRelationTitle19970010146Analytic Primary1996 NASA-ASEE-Stanford Summer Faculty Fellowship Program
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