NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
myosin heavy chain gene expression in developing neonatal skeletal muscle: involvement of the nerve, gravity, and thyroid stateThe myosin heavy chain (MHC) gene family encodes at least six MHC proteins (herein designated as neonatal, embryonic, slow type I (beta), and fast IIa, IIx, and IIb) that are expressed in skeletal muscle in a muscle-specific and developmentally-regulated fashion. At birth, both antigravity (e.g. soleus) and locomotor (e.g., plantaris) skeletal muscles are undifferentiated relative to the adult MHC phenotype such that the neonatal and embryonic MHC isoforms account for 80 - 90% of the MHC pool in a fast locomotor muscle; whereas, the embryonic and slow, type I isoforms account for approx. 90% of the pool in a typical antigravity muscle. The goal of this study was to investigate the role of an intact nerve, gravity and thyroid hormone (T3), as well as certain interactions of these interventions, on MHC gene expression in developing neonatal skeletal muscles of rodents.
Document ID
20000020587
Document Type
Conference Paper
Authors
Baldwin, K. M.
(California Univ. Irvine, CA United States)
Adams, G.
(California Univ. Irvine, CA United States)
Haddad, F.
(California Univ. Irvine, CA United States)
Zeng, M.
(California Univ. Irvine, CA United States)
Qin, A.
(California Univ. Irvine, CA United States)
Qin, L.
(California Univ. Irvine, CA United States)
McCue, S.
(California Univ. Irvine, CA United States)
Bodell, P.
(California Univ. Irvine, CA United States)
Date Acquired
August 19, 2013
Publication Date
January 1, 1999
Publication Information
Publication: Proceedings of the First Biennial Space Biomedical Investigators' Workshop
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NIH-NS-33483
CONTRACT_GRANT: NAG2-942
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

Related Records

IDRelationTitle20000020485Analytic PrimaryProceedings of the First Biennial Space Biomedical Investigators' Workshop
Document Inquiry