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salivary pharmacodynamics and bioavailability of promethazine in human subjectsThe acute effects of exposure to microgravity include the development of space motion sickness which usually requires therapeutic intervention. The current drug of choice, promethazine (PMZ), has side effects which include nausea, drowsiness, dizziness, sedation and impaired psychomotor performance. In a ground-based study with commercial airline pilots and shuttle simulator trainers, we measured sleep and psychomotor performance variables, and physiological variables such as blood pressure and heart rate, as a function of circulating drug concentrations in the body. We evaluated a non-invasive sampling method (saliva) as a means of assessing pharmacodynamics following a single intramuscular (IM) dose of PMZ.
Document ID
20000020626
Document Type
Conference Paper
Authors
Putcha, Lakshmi
(NASA Johnson Space Center Houston, TX United States)
Harm, Deborah L.
(NASA Johnson Space Center Houston, TX United States)
Nimmagudda, Ram
(Wyle Labs., Inc. Houston, TX United States)
Berens, Kurt L.
(Wyle Labs., Inc. Houston, TX United States)
Bourne, David W. A.
(Oklahoma Univ. Oklahoma City, OK United States)
Date Acquired
August 19, 2013
Publication Date
January 1, 1999
Publication Information
Publication: Proceedings of the First Biennial Space Biomedical Investigators' Workshop
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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IDRelationTitle20000020485Analytic PrimaryProceedings of the First Biennial Space Biomedical Investigators' Workshop
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