NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
nsbri radiation effects: carcinogenesis in sprague-dawley rats irradiated with iron ions, protons, or photonsOur ability to confidently develop appropriate countermeasures for radiations in space in terms of shielding and design of a spacecraft, the mission scenario, or chemoprevention is severely limited by the uncertainties in both the risk itself and the change in that risk with intervention. Despite the fact that the risk of carcinogenesis from exposures of personnel to radiations on long-term missions is considered one of the worst hazards in space, only a limited amount of in-vivo data exist for tumor induction from exposures to protons or energetic heavy ions (HZEs) at lower doses. The most extensive work remains the landmark study. for tumor development in the harderian gland of the mouse. The objective of this study is to characterize the level of risk for tumor induction in another relevant animal model. Subsequent experiments are designed to test the hypothesis that the level of risk can be reduced by pharmaceutical intervention in the promoting and progressing stages of the disease rather than in the initiating stage. The work presented here results from a cooperative effort on the part of investigators from two projects of the Radiation-Effects Team of the National Space Biomedical Research Institute (NSBRI). The collaborating projects are the Core Project which is investigating the risk of carcinogenesis in Sprague-Dawley rats and the Chemoprevention Project which is investigating the ability of Tamoxifen to reduce the number of malignant tumors in the irradiated animals. Research at the cellular and subcellular levels is being conducted in two other projects of the Radiation-Effects Team, Cytogenetics with J. R. Williams as Principal Investigator and Mutations from Repeated DNA Sequences. Results for these other projects also are being presented at this Workshop.
Document ID
20000020639
Document Type
Conference Paper
Authors
Dicello, J. F.
(Johns Hopkins Univ. Baltimore, MD United States)
Cucinotta, F. A.
(NASA Johnson Space Center Houston, TX United States)
Gridley, D. S.
(Loma Linda Univ. CA United States)
Howard, S. P.
(Wisconsin Univ. Madison, WI United States)
Novak, G. R.
(Johns Hopkins Univ. Baltimore, MD United States)
Ricart-Arbona, R.
(Johns Hopkins Univ. Baltimore, MD United States)
Strandberg, J. D.
(Johns Hopkins Univ. Baltimore, MD United States)
Vazquez, M. E.
(Brookhaven National Lab. Upton, NY United States)
Williams, J. R.
(Johns Hopkins Univ. Baltimore, MD United States)
Zhang, Y.
(Johns Hopkins Univ. Baltimore, MD United States)
Zhou, H.
(Johns Hopkins Univ. Baltimore, MD United States)
Huso, D. L.
(Johns Hopkins Univ. Baltimore, MD United States)
Date Acquired
August 19, 2013
Publication Date
January 1, 1999
Publication Information
Publication: Proceedings of the First Biennial Space Biomedical Investigators' Workshop
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

Related Records

IDRelationTitle20000020485Analytic PrimaryProceedings of the First Biennial Space Biomedical Investigators' Workshop
Document Inquiry