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context-specific adaptation of gravity-dependent vestibular reflex responses (nsbri neurovestibular project 1)Impairment of gaze and head stabilization reflexes can lead to disorientation and reduced performance in sensorimotor tasks such as piloting of spacecraft. Transitions between different gravitoinertial force (gif) environments - as during different phases of space flight - provide an extreme test of the adaptive capabilities of these mechanisms. We wish to determine to what extent the sensorimotor skills acquired in one gravity environment will transfer to others, and to what extent gravity serves as a context cue for inhibiting such transfer. We use the general approach of adapting a response (saccades, vestibuloocular reflex: VOR, or vestibulocollic reflex: VCR) to a particular change in gain or phase in one gif condition, adapting to a different gain or phase in a second gif condition, and then seeing if gif itself - the context cue - can recall the previously-learned adapted responses. Previous evidence indicates that unless there is specific training to induce context-specificity, reflex adaptation is sequential rather than simultaneous. Various experiments in this project investigate the behavioral properties, neurophysiological basis, and anatomical substrate of context-specific learning, using otolith (gravity) signals as a context cue. In the following, we outline the methods for all experiments in this project, and provide details and results on selected experiments.
Document ID
Document Type
Conference Paper
Shelhamer, Mark
(Johns Hopkins Univ. Baltimore, MD United States)
Goldberg, Jefim
(Baylor Coll. of Medicine Houston, TX United States)
Minor, Lloyd B.
(Johns Hopkins Univ. Baltimore, MD United States)
Paloski, William H.
(NASA Johnson Space Center Houston, TX United States)
Young, Laurence R.
(Massachusetts Inst. of Tech. Cambridge, MA United States)
Zee, David S.
(Johns Hopkins Univ. Baltimore, MD United States)
Date Acquired
August 19, 2013
Publication Date
January 1, 1999
Publication Information
Publication: Proceedings of the First Biennial Space Biomedical Investigators' Workshop
Subject Category
Aerospace Medicine
Distribution Limits
Work of the US Gov. Public Use Permitted.

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IDRelationTitle20000020485Analytic PrimaryProceedings of the First Biennial Space Biomedical Investigators' Workshop
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