National Space Biomedical Research InstituteThis report summarizes the activities of the National Space Biomedical Research Institute (NSBRI) during FY 1999, the second full year of existence of the NSBRI's research program, and is prepared in accordance with Cooperative Agreement NCC9-58 between NASA's Lyndon B. Johnson Space Center and Baylor College of Medicine (NSBRI). The report consists of progress reports on projects related to the effects of microgravity and space on physiology. The research is broken up in nine areas: (1) Bone loss, (2) Cardiovascular alterations, (3) human performance, (3) immunology, infection and hematology, (4) muscle alterations and atrophy,(5) Neurovestibular adaptation, radiation effects, (6) technology development, and (7) synergy projects.
IDRelationTitle20000029476WorkGH/IGF-I Transgene Expression on Muscle Homeostasis20000029459WorkThe Effects of Partial Mechanical Loading and Ibandronate on Skeletal Tissues in the Adult Rat Hindquarter Suspension Model for Microgravity20000029482WorkContext-Specific Adaptation of Gravity-Dependent Vestibular Reflex Responses20000029478WorkMolecular Signaling in Muscle Plasticity20000029462WorkCardiovascular Deconditioning in Humans: Alteration in Cardiovascular Regulation and Function During Simulated Microgravity20000029460WorkSkeletal Structural Consequences of Reduced Gravity Environments20000029472WorkSpace Flight Immunodeficiency20000029486WorkRadiation-Induced Cytogenetic Damage as a Predictor of Cancer Risk for Protons and Fe Ions20000029467WorkCircadian Entrainment, Sleep-Wake Regulation and Neurobehavioral Performance During Extended Duration Space Flight20000029461WorkCardiovascular Deconditioning in Humans: Human Studies Core20000029469WorkQuantitative EEG Monitoring of Vigilance: Effects of Sleep Deprivation, Circadian Phase and Sympathetic Activation20000029495WorkSustained Partial Sleep Deprivation: Effects on Immune Modulation and Growth Factors20000029488WorkMiniature X-Ray Bone Densitometer20000029458WorkBone Blood Flow During Simulated Microgravity: Physiological and Molecular Mechanisms20000029479WorkActivity Dependent Signal Transduction in Skeletal Muscle20000029466WorkNon-Invasive Assessment of Susceptibility to Ventricular Arrhythmias During Simulated Microgravity20000029465WorkComputational Models of the Cardiovascular System and Its Response to Microgravity20000029474WorkDNA Probe Design for Preflight and Inflight Microbial Monitoring20000029492WorkAlterations in Cardiovascular Regulation and Function During Long-Term Simulated Microgravity20000029468WorkCountermeasures to Neurobehavioral Deficits from Cumulative Partial Sleep Deprivation During Space Flight20000029494WorkVisual- and Vestibular-Autonomic Influence on Short-Term Cardiovascular Regulatory Mechanisms20000029484WorkAdvanced Techniques for Assessment of Postural and Locomotor Ataxia, Spatial Orientation, and Gaze Stability20000029477WorkPharmacological Inhibitors of the Proteosome in Atrophying Muscles20000029491WorkIn-Situ Spectrometry of Neutrons20000029463WorkRenal and Cardio-Endocrine Responses in Humans to Simulated Microgravity20000029457WorkNovel Receptor-Based Countermeasures to Microgravity-Induced Bone Loss20000029480WorkMolecular Mechanisms Regulating Muscle Fiber Composition Under Microgravity20000029473WorkImmune Function and Reactivation of Latent Viruses20000029490WorkMiniature Time-of-Flight Mass Spectrometer20000029464WorkRodent Studies of Cardiovascular Deconditioning20000029483WorkVisual Orientation in Unfamiliar Gravito-Inertial Environments20000029487WorkQuantitation of Radiation Induced Deletion and Recombination Events Associated with Repeated DNA Sequences20000029493WorkAcute Total and Chronic Partial Sleep Deprivation: Effects on Neurobehavioral Functions, Waking EEG and Renin-Angiotensin System20000029485WorkRadiation Effects: Core Project20000029471WorkPrincipal Investigator-in-a-Box20000029489WorkInstrumentation for Non-Invasive Assessment of Cardiovascular Regulation20000029457WorkNovel Receptor-Based Countermeasures to Microgravity-Induced Bone Loss20000029458WorkBone Blood Flow During Simulated Microgravity: Physiological and Molecular Mechanisms20000029459WorkThe Effects of Partial Mechanical Loading and Ibandronate on Skeletal Tissues in the Adult Rat Hindquarter Suspension Model for Microgravity20000029460WorkSkeletal Structural Consequences of Reduced Gravity Environments20000029461WorkCardiovascular Deconditioning in Humans: Human Studies Core20000029462WorkCardiovascular Deconditioning in Humans: Alteration in Cardiovascular Regulation and Function During Simulated Microgravity20000029463WorkRenal and Cardio-Endocrine Responses in Humans to Simulated Microgravity20000029464WorkRodent Studies of Cardiovascular Deconditioning20000029465WorkComputational Models of the Cardiovascular System and Its Response to Microgravity20000029466WorkNon-Invasive Assessment of Susceptibility to Ventricular Arrhythmias During Simulated Microgravity20000029467WorkCircadian Entrainment, Sleep-Wake Regulation and Neurobehavioral Performance During Extended Duration Space Flight20000029468WorkCountermeasures to Neurobehavioral Deficits from Cumulative Partial Sleep Deprivation During Space Flight20000029469WorkQuantitative EEG Monitoring of Vigilance: Effects of Sleep Deprivation, Circadian Phase and Sympathetic Activation20000029470WorkOn-Line Analysis of Physiologic and Neurobehavioral Variables During Long-Duration Space Missions20000029471WorkPrincipal Investigator-in-a-Box20000029472WorkSpace Flight Immunodeficiency20000029473WorkImmune Function and Reactivation of Latent Viruses20000029474WorkDNA Probe Design for Preflight and Inflight Microbial Monitoring20000029476WorkGH/IGF-I Transgene Expression on Muscle Homeostasis20000029477WorkPharmacological Inhibitors of the Proteosome in Atrophying Muscles20000029478WorkMolecular Signaling in Muscle Plasticity20000029479WorkActivity Dependent Signal Transduction in Skeletal Muscle20000029480WorkMolecular Mechanisms Regulating Muscle Fiber Composition Under Microgravity20000029482WorkContext-Specific Adaptation of Gravity-Dependent Vestibular Reflex Responses20000029483WorkVisual Orientation in Unfamiliar Gravito-Inertial Environments20000029484WorkAdvanced Techniques for Assessment of Postural and Locomotor Ataxia, Spatial Orientation, and Gaze Stability20000029485WorkRadiation Effects: Core Project20000029486WorkRadiation-Induced Cytogenetic Damage as a Predictor of Cancer Risk for Protons and Fe Ions20000029487WorkQuantitation of Radiation Induced Deletion and Recombination Events Associated with Repeated DNA Sequences20000029488WorkMiniature X-Ray Bone Densitometer20000029489WorkInstrumentation for Non-Invasive Assessment of Cardiovascular Regulation20000029490WorkMiniature Time-of-Flight Mass Spectrometer20000029491WorkIn-Situ Spectrometry of Neutrons20000029492WorkAlterations in Cardiovascular Regulation and Function During Long-Term Simulated Microgravity20000029493WorkAcute Total and Chronic Partial Sleep Deprivation: Effects on Neurobehavioral Functions, Waking EEG and Renin-Angiotensin System20000029494WorkVisual- and Vestibular-Autonomic Influence on Short-Term Cardiovascular Regulatory Mechanisms20000029495WorkSustained Partial Sleep Deprivation: Effects on Immune Modulation and Growth Factors20000029496WorkChemoprevention of Radiation Induced Rat Mammary Neoplasms20000029496WorkChemoprevention of Radiation Induced Rat Mammary Neoplasms20000029470WorkOn-Line Analysis of Physiologic and Neurobehavioral Variables During Long-Duration Space Missions