Experiment M-1: Cardiovascular Conditioning

Intermittent venous occlusion of the extremities of man, during weightlessness simulation studies, has been demonstrated to be effective in preventing or mitigating the orthostatic hypotension observed following such simulations. A similar preventive measure was employed on the pilot of Gemini V with a view to determining the efficacy of pulsatile leg cuffs in preventing or lessening the orthostatic hypotension observed following previous space flights. Unfortunately, the cuff device was operative continuously during only the first 4 days of the 8-day mission. Post flight tilt-table responses of the command pilot and the pilot were considerably different, but the data cannot be construed as a conclusive demonstration that the observed differences were the result of the action of the pulsatile cuffs. The differences in the tilt responses of the Gemini V flight crew may be only a reflection of individual variability so commonly observed in biological experimentation. More data shall be required before a judgement can be rendered as to the efficacy of the pulsatile-leg-cuff technique in lessening postflight postural or orthostatic hypotension.