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Therapeutic potential of implanted tissue-engineered bioartificial muscles delivering recombinant proteins to the sheep heartTissue-engineered primary adult sheep muscle cells genetically engineered to express either rhVEGF or rhIGF-1 secreted the bioactive proteins locally in the sheep heart for at least 30 days.
Document ID
20040088257
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Lu, Y. (Brown University School of Medicine and Miriam Hospital Providence, RI 02906, United States)
Shansky, J.
Del Tatto, M.
Ferland, P.
McGuire, S.
Marszalkowski, J.
Maish, M.
Hopkins, R.
Wang, X.
Kosnik, P.
Nackman, M.
Lee, A.
Creswick, B.
Vandenburgh, H.
Date Acquired
August 21, 2013
Publication Date
June 1, 2002
Publication Information
Publication: Annals of the New York Academy of Sciences
Volume: 961
ISSN: 0077-8923
Subject Category
Life Sciences (General)
Report/Patent Number
ISSN: 0077-8923
Funding Number(s)
CONTRACT_GRANT: HL 60502
CONTRACT_GRANT: AG 15415
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Musculoskeletal
Non-NASA Center
Myocardium/cytology
Muscles/cytology
Biocompatible Materials
Endothelial Growth Factors/biosynthesis/genetics
Vascular Endothelial Growth Factors
Neovascularization, Physiologic
Time Factors
Muscle, Skeletal/cytology
Support, U.S. Gov't, P.H.S
Lymphokines/biosynthesis/genetics
Sheep
Gene Therapy/methods
Insulin-Like Growth Factor I/biosynthesis/genetics
Recombinant Proteins/metabolism
Animals
Support, U.S. Gov't, Non-P.H.S
Vascular Endothelial Growth Factor A
Immunohistochemistry

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