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In vitro evolution of nucleic acidsThe author reviews recent published reports of in vitro selection and evolution of nucleic acids. These nucleic acids will bind to a target ligand or catalyze a specific chemical reaction. The terms aptamers and systematic evolution of ligands by exponential enrichment (SELEX) are explained. The review focuses on protein binders, small molecule binders, and ribozymes obtained by directed evolution. The reference list identifies articles of special or outstanding interest.
Document ID
20040089662
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
doi:10.1016/S0959-440X(94)90100-7
Authors
Joyce, G. F. (The Scripps Research Institute La Jolla, United States)
Miller, S. L.
Date Acquired
August 21, 2013
Publication Date
January 1, 1994
Publication Information
Publication: Current opinion in structural biology
Volume: 4
ISSN: 0959-440X
Subject Category
Exobiology
Report/Patent Number
ISSN: 0959-440X
Distribution Limits
Public
Copyright
Other
Keywords
Review
Non-NASA Center
Review Literature
NASA Discipline Exobiology
Nucleic Acids/chemical synthesis/chemistry
Directed Molecular Evolution
RNA, Catalytic/chemical synthesis/chemistry
RNA/chemistry
DNA/chemistry
DNA-Directed RNA Polymerases
Protein Binding
RNA-Directed DNA Polymerase
Polymerase Chain Reaction
Ligands

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