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A convenient synthesis of a novel nucleoside analogue: 4-(alpha-diformyl-methyl)-1-(beta-D-ribofuranosyl)-2-pyrimidinoneThe nucleoside analogue 4-(alpha-diformyl-methyl)-1-(beta-D-ribofuranosyl)-2-pyrimidinone (5) was prepared from the corresponding 4-methyl pyrimidinone nucleoside by means of the Vilsmeier reaction. The unprotected nucleoside can be phosphorylated directly with phosphorus oxychloride in triethyl phosphate.
Document ID
20040141484
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Gao, K. (Salk Institute for Biological Studies La Jolla, California 92037, United States)
Orgel, L. E.
Bada, J. L.
Date Acquired
August 22, 2013
Publication Date
May 1, 2000
Publication Information
Publication: Nucleosides, nucleotides & nucleic acids
Volume: 19
Issue: 5-6
ISSN: 1525-7770
Subject Category
Exobiology
Report/Patent Number
ISSN: 1525-7770
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Exobiology
Pyrimidine Nucleosides/chemical synthesis
Cytidine/chemical synthesis
Furans/chemistry
Spectrum Analysis, Mass
Molecular Structure
Support, U.S. Gov't, Non-P.H.S
Magnetic Resonance Spectroscopy
Chromatography, High Pressure Liquid

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