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The effects of interferon-alpha/beta in a model of rat heart transplantationInterferons have multiple immunologic effects. One such effect is the activation of expression of cell surface antigens. Interferon alpha/beta enhance expression of class I but not class II histocompatibility antigens. Contradictory information has been published regarding the effect of interferon-alpha/beta administration in patients with kidney transplantation. In a model of rat heart transplantation we demonstrated that administration of interferon-alpha/beta accelerated rejection in a dose-dependent fashion in the absence of maintenance cyclosporine. Animals treated with maintenance cyclosporine had evidence of increased rejection at 20 days that was resolved completely at 45 days with cyclosporine alone.
Document ID
20050000608
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Slater, A. D. (University of Louisville KY 40292)
Klein, J. B.
Sonnenfeld, G.
Ogden, L. L. 2nd
Gray, L. A. Jr
Date Acquired
August 22, 2013
Publication Date
September 1, 1992
Publication Information
Publication: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Volume: 11
Issue: 5
ISSN: 1053-2498
Subject Category
Life Sciences (General)
Report/Patent Number
ISSN: 1053-2498
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Regulatory Physiology
Non-NASA Center
Interferon-alpha/pharmacology
Heart Transplantation
Interferon-beta/pharmacology
Graft Rejection
Rats
Rats, Inbred Lew
Support, Non-U.S. Gov't
Cyclosporine/administration & dosage
Animals

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