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Delivery of Probiotics in the Space Food SystemThe addition of probiotic bacteria to the space food system is expected to confer immunostimulatory benefits on crewmembers during spaceflight, counteracting the immune dysregulation that has been documented in spaceflight. Specifically, the probiotic Lactobacillus acidophilus has been shown to promote health benefits including antagonism towards and inhibition of virulence related gene expression in pathogens, mucosal stimulation of immune cells, and a reduction in the occurrence and duration of cold and flu‐like symptoms. The optimum delivery system for probiotics has not been determined for spaceflight, where the food system is shelf stable and the lack of refrigeration prevents the use of traditional dairy delivery methods. This work proposes to determine whether L. acidophilus is more viable, and therefore more likely to confer immune benefit, when delivered in a capsule form or when delivered in nonfat dry milk powder with a resuscitation opportunity upon rehydration, following 0, 4, and 8 months of storage at ‐80degC, 4degC, and 22degC, and both prior to and after challenge with simulated gastric and intestinal juices. We hypothesize that the low moisture neutral dairy matrix provided by the nonfat dry milk, and the rehydration step prior to consumption, will extend probiotic viability and stress tolerance compared to a capsule during potential storage conditions in spaceflight and in simulated digestion conditions.
Document ID
Document Type
Castro, S. L.
(NASA Johnson Space Center Houston, TX, United States)
Ott, C. M.
(NASA Johnson Space Center Houston, TX, United States)
Douglas, G. L.
(NASA Johnson Space Center Houston, TX, United States)
Date Acquired
June 3, 2014
Publication Date
February 12, 2014
Subject Category
Man/System Technology And Life Support
Report/Patent Number
Meeting Information
2014 NASA Human Research Program Investigators'' Workshop (HRP 2014)(Galveston,TX)
Distribution Limits
Work of the US Gov. Public Use Permitted.

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IDRelationTitle20140005954See AlsoDelivery of Probiotics in the Space Food System
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