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The Digital Astronaut Project Bone Remodeling ModelUnder the conditions of microgravity, astronauts lose bone mass at a rate of 1% to 2% a month, particularly in the lower extremities such as the proximal femur: (1) The most commonly used countermeasure against bone loss has been prescribed exercise, (2) However, current exercise countermeasures do not completely eliminate bone loss in long duration, 4 to 6 months, spaceflight, (3,4) leaving the astronaut susceptible to early onset osteoporosis and a greater risk of fracture later in their lives. The introduction of the Advanced Resistive Exercise Device, coupled with improved nutrition, has further minimized the 4 to 6 month bone loss. But further work is needed to implement optimal exercise prescriptions, and (5) In this light, NASA's Digital Astronaut Project (DAP) is working with NASA physiologists to implement well-validated computational models that can help understand the mechanisms of bone demineralization in microgravity, and enhance exercise countermeasure development.
Document ID
20140006747
Acquisition Source
Glenn Research Center
Document Type
Conference Paper
Authors
Pennline, James A.
(NASA Glenn Research Center Cleveland, OH United States)
Mulugeta, Lealem
(Universities Space Research Association Houston, TX, United States)
Lewandowski, Beth E.
(NASA Glenn Research Center Cleveland, OH United States)
Thompson, William K.
(NASA Glenn Research Center Cleveland, OH United States)
Sibonga, Jean D.
(NASA Johnson Space Center Houston, TX, United States)
Date Acquired
June 4, 2014
Publication Date
February 12, 2014
Subject Category
Aerospace Medicine
Report/Patent Number
GRC-E-DAA-TN13262
Meeting Information
Meeting: 2014 Human Research Program Investigators'' Workshop
Location: Galveston, TX
Country: United States
Start Date: February 12, 2014
End Date: February 13, 2014
Sponsors: NASA Johnson Space Center
Funding Number(s)
WBS: WBS 516724.02.02.10
Distribution Limits
Public
Copyright
Public Use Permitted.
Keywords
Femoral Neck
Microgravity
Bone loss
Mathematical Model
Bone Remodeling
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