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Oscillation of Angiogenesis and Vascular Dropout in Progressive Human Vascular DiseaseWhen analyzed by VESsel GENeration Analysis (VESGEN) software, vascular patterns provide useful integrative read-outs of complex, interacting molecular signaling pathways. Using VESGEN, we recently discovered and published our innovative, surprising findings that angiogenesis oscillated with vascular dropout throughout progression of diabetic retinopathy, a blinding vascular disease. Our findings provide a potential paradigm shift in the current prevailing view on progression and treatment of this disease, and a new early-stage window of regenerative therapeutic opportunities. The findings also suggest that angiogenesis may oscillate with vascular disease in a homeostatic-like manner during early stages of other inflammatory progressive diseases such as cancer and coronary vascular disease.
Document ID
20150010324
Acquisition Source
Glenn Research Center
Document Type
Presentation
Authors
Parsons-Wingerter, Patricia
(NASA Glenn Research Center Cleveland, OH, United States)
Date Acquired
June 10, 2015
Publication Date
February 8, 2010
Subject Category
Aerospace Medicine
Mathematical And Computer Sciences (General)
Life Sciences (General)
Report/Patent Number
E-661298
Funding Number(s)
WBS: WBS 667266.01.03.0543.02
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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