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Optic Nerve Sheath Mechanics in VIIP SyndromeVisual Impairment and Intracranial Pressure (VIIP) syndrome results in a loss of visual function and occurs in astronauts following long-duration spaceflight. Understanding the mechanisms that lead to the ocular changes involved in VIIP is of critical importance for space medicine research. Although the exact mechanisms of VIIP are not yet known, it is hypothesized that microgravity-induced increases in intracranial pressures (ICP) drive the remodeling of the optic nerve sheath, leading to compression of the optic nerve which in turn may reduce visual acuity. Some astronauts present with a kink in the optic nerve after return to earth, suggesting that tissue remodeling in response to ICP increases may be taking place. The goal of this work is to characterize the mechanical properties of the optic nerve sheath (dura mater) to better understand its biomechanical response to increased ICP.
Document ID
Acquisition Source
Glenn Research Center
Document Type
Raykin, Julia
(Georgia Inst. of Tech. Atlanta, GA, United States)
Feola, Andrew
(Georgia Inst. of Tech. Atlanta, GA, United States)
Gleason, Rudy
(Georgia Inst. of Tech. Atlanta, GA, United States)
Mulugeta, Lealem
(University Space Research Association Houston, TX, United States)
Myers, Jerry
(NASA Glenn Research Center Cleveland, OH, United States)
Nelson, Emily
(NASA Glenn Research Center Cleveland, OH, United States)
Samuels, Brian
(Alabama Univ. Birmingham, AL, United States)
Ethier, C. Ross
(Georgia Inst. of Tech. Atlanta, GA, United States)
Date Acquired
September 24, 2015
Publication Date
June 17, 2015
Subject Category
Aerospace Medicine
Report/Patent Number
Meeting Information
Meeting: Summer Biomechanics, Bioengineering and Biotransport Conference
Location: Snowbird, UT
Country: United States
Start Date: June 17, 2015
End Date: June 20, 2015
Sponsors: National Science Foundation, National Inst. of Health
Funding Number(s)
WBS: WBS 516724.01.02.10
Distribution Limits
Public Use Permitted.
mathematical models
intraocular pressure
intracranial pressure
eye (anatomy)
fluid shift (biological)
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