Inflight Pharmacokinetic and Pharmacodynamic Responses to Medications Commonly Used in SpaceflightResearchers do not know if medications act the same in the spaceflight environment as they do on Earth. Aspects of the spaceflight environment (low gravity, radiation exposure, closed environment, stress) have been shown to alter human physiology. Some of these physiological changes could be expected to alter either pharmacokinetics (PK, how the body absorbs, distributes, metabolizes and excretes administered medications) or pharmacodynamics (PD, receptors or signaling systems that are the targets of medication action). Anecdotal data has suggested that, at least for certain medications or indications, inflight medication efficacy is poor. In order to prepare for exploration missions where speedy evacuation to Earth may not be a possibility, the likelihood of unexpected medication action must be determined.
Document ID
20150021496
Acquisition Source
Johnson Space Center
Document Type
Conference Paper
Authors
Wotring, V. E. (Baylor Coll. of Medicine Houston, TX, United States)
Derendorf, H. (Florida Univ. Gainesville, FL, United States)
Kast, J. (Florida Univ. Gainesville, FL, United States)
Barger, L. (Harvard Medical School Boston, MA, United States)
Basner, M. (Pennsylvania Univ. Philadelphia, PA, United States)
Date Acquired
November 20, 2015
Publication Date
February 8, 2016
Subject Category
Aerospace Medicine
Report/Patent Number
JSC-CN-34788
Meeting Information
Meeting: NASA Human Research Program Investigators'' Workshop (HRP IWS 2016)