NTRS - NASA Technical Reports Server

Back to Results
Mapping Bone Mineral Density Obtained by Quantitative Computed Tomography to Bone Volume FractionMethods for relating or mapping estimates of volumetric Bone Mineral Density (vBMD) obtained by Quantitative Computed Tomography to Bone Volume Fraction (BVF) are outlined mathematically. The methods are based on definitions of bone properties, cited experimental studies and regression relations derived from them for trabecular bone in the proximal femur. Using an experimental range of values in the intertrochanteric region obtained from male and female human subjects, age 18 to 49, the BVF values calculated from four different methods were compared to the experimental average and numerical range. The BVF values computed from the conversion method used data from two sources. One source provided pre bed rest vBMD values in the intertrochanteric region from 24 bed rest subject who participated in a 70 day study. Another source contained preflight vBMD values from 18 astronauts who spent 4 to 6 months on the ISS. To aid the use of a mapping from BMD to BVF, the discussion includes how to formulate them for purpose of computational modeling. An application of the conversions would be used to aid in modeling of time varying changes in vBMD as it relates to changes in BVF via bone remodeling and/or modeling.
Document ID
Acquisition Source
Glenn Research Center
Document Type
Technical Memorandum (TM)
Pennline, James A.
(NASA Glenn Research Center Cleveland, OH United States)
Mulugeta, Lealem
(Universities Space Research Association Houston, TX, United States)
Date Acquired
June 29, 2017
Publication Date
June 1, 2017
Subject Category
Aerospace Medicine
Life Sciences (General)
Report/Patent Number
Funding Number(s)
WBS: WBS 516724.01.02.10
Distribution Limits
Public Use Permitted.
No Preview Available