Hydrostatic and Physiologic Contributions to Intraocular Pressure Change During Postural Change

Many studies have observed that intraocular pressure (IOP) is dependent on tilt angle () during postural change. In this work, we aggregated 36 independent datasets from 30 published articles, representing 821 subjects, which reported data on IOP during postural change. From this data, we developed a generalized quantitative relationship between IOP and . We then compared the experimentally derived results to simulated predictions generated by our lumped parameter model of the eye, LPEye, considering only hydrostatic effects. The difference between the analytical and simulated values of IOP can be used to quantify the physiologic regulatory contribution.