Teal Cycle Ergometer Vibration Isolation and Stabilization System Human-in-the-Loop Ground Evaluation for Long-Duration Spaceflight

Purpose: To counter the deleterious effects of weightlessness on the cardiopulmonary system, astronauts living on the International Space Station exercise on a variety of countermeasure equipment including the Cycle Ergometer Vibration Isolation and Stabilization System (CEVIS). Operational since 2001, the onboard CEVIS will be replaced by a new model, known as Teal CEVIS (TC). As a part of ground evaluation, TC hardware underwent human-in-the-loop (HITL) testing to verify the TC hardware produces workloads that elicit physiologic responses comparable to a laboratory cycle ergometer (LAB). Methods: Seven subjects (5 M/2 F) performed submaximal cycle ergometer testing with indirect calorimetry measures on TC and LAB on separate test days. Testing consisted of graded 30 watt increases in workload until subjects reached 85% of age-predicted max heart rate (HR). Exercise outcomes included rate of oxygen uptake (VO2; liters/min), rate of energy expenditure (REE; kcal/min), and HR (beats/min). Linear mixed models (LMM) were fitted to compare VO2, REE, and HR responses between devices across power outputs with fixed effects for power (P) and device (D) and with random effects for subject. LMM effect coefficients (β), std errors (SE), pseudo-partial R2 of effects (pR2), and model likelihood ratio statistics (χ2, Pr(> chisq); α<.05) are provided. Results: LMM main effects for P and D were observed for VO2 (βp=.0107, SE = .0002, pR2=0.97; βd = -0.075, SE = 0.019, pR2=0.14; χ2(1)= 13.57, p<.001), such that VO2 was higher across stages on TC. Main effects of P and D were observed for REE (βp= .0586, SE = 0.001, pR2= 0.97; βd = -0.33208, SE = 0.099, pR2= 0.056; χ2(1)=10.481, p < .01), such that REE was higher across power outputs on TC. A P x D interaction was observed for HR, along with main effects for P and D (βp x d =-0.048, SE = 0.02, pR2=0.048; βp= 0.42, SE = 0.016, pR2=0.87; χ2(1) = 5.398, p = 0.02), such that higher workloads elicited a greater difference in HR between devices. Conclusions: HITL results show, TC elicits greater physiologic responses across power outputs compared to LAB. However, pR2 for device effects show small differences between devices. Therefore, TC can be expected to provide appropriate physiological stimulus across workloads and be considered a reliable tool to mitigate the effects of weightlessness.