Crew State and Risk Model (CSRM) - Medication Impacts on Physiologic Models for Exploration Class EVA Predictive Modeling and Operations

EVA and Environmental Physiology Laboratory (EEPL) wanted to expand upon the previous CSRM Physiologic Map to visually demonstrate the impact of medications on various modeling inputs that map to the seven physiologic models. It is acknowledged various physiologic states present during EVA could impact drug pharmacokinetics (i.e. pressure changes, core body temperature), which could impact pharmacodynamics. However, that is outside the scope of this document. The medications below represent the authors’ assumption of what medications will be available and able to impact an Artemis EVA and do not include the full ISS formulary, a final Artemis medical kit, or additional personal medications for individual crewmember’s chronic medical conditions.