The ABCs of Spaceflight: Evaluating the Impact of Spaceflight on ABC Proteins (P-Glycoprotein) in the Blood Brain Barrier

Both astronauts and other model organisms experience negative effects from spaceflight, such as Blood-Brain Barrier (BBB) leakage—this vital barrier protects the brain from harmful substances. This leakage results from oxidative stress and neuroinflammation caused by proinflammatory cytokines which damage surrounding tissue. Thus, our proposal uses Drosophila Melanogaster(Fruit fly) transcriptomics data from OSD-588 to investigate the role of microgravity on the BBB and methods to mitigate these implications,