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Enabling Open and Interoperable Science: Multi-Omics Data Processing Platform with NASA GeneLab Standardized Bioinformatics Workflows for Space and Earth ResearchMulti-omics biological data continues to be generated at an astounding pace. Genomics, transcriptomics, metabolomics, and proteomics, or collectively known as multi-omics data, are used to assess biological functions, and provide invaluable insights into human, animal, plant, and environmental health both on Earth and in Space. Despite the abundance of these valuable data, the need for bioinformatics expertise, particularly as it relates to the niche filed of space biology, and a lack of accessible resources for processing these data limit their usefulness in deriving biological insights.

The NASA Open Science Data Repository (OSDR) provides access to omics data from various spaceflight and analog studies. To enhance the accessibility and reusability of these data, GeneLab (part of OSDR) designs and implements standardized, community-driven, open-source bioinformatics workflows to transform raw omics data into standardized processed data. Currently, GeneLab-processed data from hundreds of space studies have been reused for meta-analyses. This has led to new insights and scientific publications that extend beyond the initial research, thereby enriching our understanding of molecular-scale biological responses to the space environment.

To make these bioinformatics workflows open and accessible, GeneLab teamed up with DOE-funded initiatives, including the National Microbiome Data Collaborative (NMDC), to create the NASA EDGE [Empowering the Development of Genomics Expertise] Bioinformatics web-based platform. NASA EDGE utilizes shared compute resources to run the GeneLab standardized bioinformatics workflows, which eliminates the need for researchers to have their own high performance computing cluster. The web-based platform makes complicated biological analyses incredibly easy to perform, thus expanding the reach of these analyses to bioinformatics novices, students, and even citizen scientists enabling them to contribute to scientific discoveries and progress.

The authors will demonstrate how the NASA EDGE platform can be used to process microbial omics data hosted on OSDR as well as user-generated omics datasets using GeneLab’s standard workflows.
Document ID
20240015371
Acquisition Source
Ames Research Center
Document Type
Presentation
Authors
Amanda M. Saravia-Butler
(Amentum Chantilly, Virginia, United States)
Julia M. Kelliher
(Los Alamos National Laboratory Los Alamos, United States)
Alexis Torres
(Blue Marble Space Seattle, Washington, United States)
Lauren M. Sanders
(Blue Marble Space Institute of Science Seattle, Washington, United States)
Samrawit G. Gebre
(Ames Research Center Mountain View, United States)
Date Acquired
December 2, 2024
Subject Category
Space Sciences (General)
Meeting Information
Meeting: American Society for Gravitational and Space Research (ASGSR) 2024 Conference
Location: San Juan
Country: PR
Start Date: December 3, 2024
End Date: December 7, 2024
Sponsors: American Society for Gravitational and Space Research
Funding Number(s)
CONTRACT_GRANT: 80ARC024DA004
Distribution Limits
Public
Copyright
Portions of document may include copyright protected material.
Technical Review
Single Expert
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