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Guidelines for Assessing the Toxic Hazard of Spacecraft Chemicals and Test MaterialsThis document describes the criteria and procedural guidelines used by the NASA / Johnson Space Center (JSC) Toxicology Group to perform toxicological evaluations. JSC Toxicology is responsible for conducting toxicological assessments and assigning toxic hazard levels (THLs) for essentially all chemicals and test materials to be used in or transported to the habitable areas of U.S. spacecraft, non-U.S. spacecraft inhabited by U.S. crew members or habitable areas of off-Earth habitats, vehicles, and spacesuits where U.S. crew members would be present, including chemicals carried by visiting spacecraft (visiting vehicles) to and from the International Space Station (ISS) or Exploration destinations. This document will focus on the assessment of chemically-induced toxicity hazards. It also briefly addresses the assessment of physical hazards associated with chemically inert substances. Other hazards, including biosafety, radiation, and flammability, are handled by other groups under different processes. The toxicological assessments, together with assessments on radioactive, biological, physical, and flammability hazards as well as impacts to environmental control systems, are incorporated into a mission-specific Hazardous Materials Summary Table (HMST).
Document ID
20250007586
Acquisition Source
Johnson Space Center
Document Type
Other - JSC numbered document
Authors
Valerie Ryder
(Johnson Space Center Houston, United States)
Date Acquired
July 28, 2025
Publication Date
July 1, 2025
Subject Category
Aerospace Medicine
Space Transportation and Safety
Report/Patent Number
JSC 26895
Funding Number(s)
WBS: 59981.04.01.01
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
Technical Review
NASA Technical Management
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