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Experimental investigation on the origin of the genetic code.A simple model of interacting complex systems of species is tested to assess the binding behavior of monomeric nucleic acid and protein components during evolution. Nine representative amino acids are immobilized by the formation of an amide linkage on a prepared chromatographic support. Selective binding of ribonucleoside 5-phosphates in these amino acids is achieved under standardized conditions, and a site-binding model is derived to characterize the binding. It is shown that the binding behavior of the reactants during nucleic acid-protein interactions depends on the nature of the base and the amino acid. The results of the study are assessed as useful for the interpretation of more complex nucleic acid-protein systems and of their role in the evolution of the cell.
Document ID
19720028099
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Saxinger, C.
Ponnamperuma, C.
(NASA Ames Research Center Exobiology Div., Moffett Field, Calif., United States)
Date Acquired
August 6, 2013
Publication Date
January 1, 1971
Publication Information
Publication: Journal of Molecular Evolution
Volume: 1
Issue: 1, 19
Subject Category
Biosciences
Accession Number
72A11765
Distribution Limits
Public
Copyright
Other

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