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The possible participation of esters as well as amides in prebiotic polymers.Demonstration that alpha-hydroxy acids may have participated in the formation of prebiological polymers in a manner similar to the participation of alpha-amino acids. Ex periments are described which indicate that the system for forming peptide bonds in present-day biological organisms is equally competent in forming ester and polyester bonds. In particular, the experiments described are directed toward answering questions regarding the action of peptidyl transferase in ester formation. Also, an attempt is made to determine whether a complete protein synthetic system can operate with transfer RNA molecules which have alpha-hydroxyl acids attached to them instead of alpha-amino acids, using both synthetic and natural mRNA. The ability of ribosomal peptidyl transferase to catalyze the formation of an ester bond as well as its normal product, the peptide bond, is demonstrated.
Document ID
19720031101
Acquisition Source
Legacy CDMS
Document Type
Conference Proceedings
Authors
Rich, A.
(MIT Cambridge, Mass., United States)
Date Acquired
August 6, 2013
Publication Date
January 1, 1971
Subject Category
Biosciences
Meeting Information
Meeting: Chemical evolution and the origin of life; Third International Conference
Location: Pont-a-Mousson
Country: France
Start Date: April 19, 1970
End Date: April 25, 1970
Accession Number
72A14767
Funding Number(s)
CONTRACT_GRANT: NGR-22-009-277
Distribution Limits
Public
Copyright
Other

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