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Parathyroid hormone - Secretion and metabolism in vivo.Gel filtration and radioimmunoassay were used to determine the molecular size and immunochemical reactivity of parathyroid hormone present in gland extracts, in the general peripheral circulation, and in parathyroid effluent blood from patients with hyperparathyroidism, as well as from calves and from cattle. It was found that parathyroid hormone secreted from the parathyroids in man and cattle is at least as large as the molecule extracted from normal bovine glands. However, once secreted into the circulation the hormone is cleaved, and one or more fragments, immunologically, dissimilar to the originally secreted hormone, constitute the dominant form of circulating immunoreactive hormone.
Document ID
19720031562
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Habener, J. F.
Powell, D.
Murray, T. M.
Mayer, G. P.
Potts, J. T., Jr.
(Massachusetts General Hospital; Harvard University Boston, Mass.; Pennsylvania, University, Kennett Square, Pa., United States)
Date Acquired
August 6, 2013
Publication Date
December 1, 1971
Publication Information
Publication: National Academy of Sciences
Subject Category
Biosciences
Accession Number
72A15228
Funding Number(s)
CONTRACT_GRANT: NIH-AM-11794
CONTRACT_GRANT: NIH-AM-04501
CONTRACT_GRANT: NIH-AM-05205
Distribution Limits
Public
Copyright
Other

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