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Hypothalamic stimulation and baroceptor reflex interaction on renal nerve activity.The basal level of mean renal nerve activity (MRNA-0) measured in anesthetized cats was found to be modified by the additive interaction of hypothalamic and baroceptor reflex influences. Data were collected with the four major baroceptor nerves either intact or cut, and with mean aortic pressure (MAP) either clamped with a reservoir or raised with l-epinephrine. With intact baroceptor nerves, MRNA stayed essentially constant at level MRNA-0 for MAP below an initial pressure P1, and fell approximately linearly to zero as MAP was raised to P2. Cutting the baroceptor nerves kept MRNA at MRNA-0 (assumed to represent basal central neural output) independent of MAP. The addition of hypothalamic stimulation produced nearly constant increments in MRNA for all pressure levels up to P2, with complete inhibition at some level above P2. The increments in MRNA depended on frequency and location of the stimulus. A piecewise linear model describes MRNA as a linear combination of hypothalamic, basal central neural, and baroceptor reflex activity.
Document ID
19720032056
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Wilson, M. F.
Ninomiya, I.
Franz, G. N.
Judy, W. V.
(West Virginia University Morgantown, W. Va., United States)
Date Acquired
August 6, 2013
Publication Date
December 1, 1971
Publication Information
Publication: American Journal of Physiology
Volume: 221
Subject Category
Biosciences
Accession Number
72A15722
Funding Number(s)
CONTRACT_GRANT: NIH-HE-10234-04
CONTRACT_GRANT: NGL-49-001-001
Distribution Limits
Public
Copyright
Other

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