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A common modality of action of simulated space stresses on the oxidative metabolism of ethylmorphine, aniline and p-nitroanisole by male rat liver.High gravity, cold and starvation elicited similar responses in male Simonson rats. These responses included a decreased rate in body weight gain, increased metabolism of aniline and p-nitroanisole, and no consistent pattern of change in the metabolism of ethylmorphine. Cold and starvation increased the amount of hepatic cytochrome P-450, while hypobaric-hyperoxia caused no change in any of the parameters measured. When 1% acetone was given to the rats in their drinking water, the effects on drug metabolism were similar to those produced by food restriction in that the metabolism of aniline and p-nitroanisole was increased, and the metabolism of ethylmorphine unchanged. The type I binding spectrum of acetone suggests that it is either a substrate, inhibitor, or both for hepatitic oxidative enzymes.
Document ID
19720048034
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Furner, R. L.
Neville, E. D.
Talarico, K. S.
Feller, D. D.
(NASA Ames Research Center Environmental Biology Div., Moffett Field, Calif., United States)
Date Acquired
August 6, 2013
Publication Date
January 1, 1972
Publication Information
Publication: Toxicology and Applied Pharmacology
Volume: 21
Subject Category
Biosciences
Accession Number
72A31700
Distribution Limits
Public
Copyright
Other

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