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Urinary Excretion of Antidiuretic Hormone in ManIt is shown that urinary excretion of ADH can be detected readily and quantitated accurately. The ADH excretion in normal subjects is inhibited following the administration of a water load and stimulated following water deprivation. It appears that measurement of ADH excretion in man provides a means of quantitating alterations in neurohypophyseal ADH secretion. By determining not only the basal excretion of ADH but also the response to such physiological influences as water loading and dehydration, it becomes possible to study the dynamics of ADH release. Thus, the ability to extract ADH efficiently from urine combined with a sensitive and specific technique for determination of ADH concentration allows the exploration of regulatory systems for ADH control in the normal state as well as the etiological role of altered ADH secretion in clinical disorders of water balance.
Document ID
19730009380
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Miller, M.
(State Univ. of New York Syracuse, NY, United States)
Date Acquired
August 7, 2013
Publication Date
November 1, 1972
Publication Information
Publication: NASA. Lyndon B. Johnson Space Center Proc. of the 1971 Manned Spacecraft Center Endocrine Program Conf.
Subject Category
Biosciences
Accession Number
73N18107
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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