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Parathyroid Hormone, Calcitonin, and Vitamin DAnalyses of secretion of parathyroid hormone during tests of stimulation and suppression of hormone-secretory activity using infusions of EDTA and calcium, respectively, have established that, in contrast to previous views, secretion of the hormone is not autonomous in many patients that have adenomatous hyperparathyroidism, but is responsive to changes in blood-calcium concentration. These findings have led to a new understanding of the pathophysiology of hormone production in hyperparathy-roidism. A related application of the diagnostic use of the radioimmunoassay is the preoperative localization of parathyroid tumors and the distinction between adenomas and chief-cell hyperplasia. Work involving catheterization and radioimmunoassay of blood samples obtained from the subclavin and innominate veins and the venae cavae, led to localization in a high percentage of patients. However, this procedure has been adopted recently to detect hormone concentration in the small veins directly draining the parathyroid glands.
Document ID
19730009385
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Potts, J. T.
(Harvard Univ. Cambridge, MA, United States)
Date Acquired
August 7, 2013
Publication Date
November 1, 1972
Publication Information
Publication: NASA. Lyndon B. Johnson Space Center Proc. of the 1971 Manned Spacecraft Center Endocrine Program Conf.
Subject Category
Biosciences
Accession Number
73N18112
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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