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Effects of endotoxin on monoamine metabolism in the rat.Examination of effects of administered endotoxin on catecholamine metabolism in the rat brain, sympathetic neurons, and adrenal medulla. It is found that endotoxin, administered intraperitoneally, lowers the norepinephrine content in peripheral sympathetic neurons and the brain, and the catecholamine content in the adrenal medulla. It also accelerates the disappearance of H3-norepinephrine from all these tissues. It is therefore suggested that the effects of endotoxin on body temperature may be mediated in part by central non-adrenergic neurons.
Document ID
19730026298
Document Type
Reprint (Version printed in journal)
Authors
Pohorecky, L. A.
Wurtman, R. J.
Taam, D.
Fine, J. (MIT, Cambridge; Boston City Hospital, Boston Mass., United States)
Date Acquired
August 7, 2013
Publication Date
July 1, 1972
Publication Information
Publication: Society for Experimental Biology and Medicine
Subject Category
BIOSCIENCES
Funding Number(s)
CONTRACT_GRANT: PHS-HE-02014
CONTRACT_GRANT: PHS-AM-11237
CONTRACT_GRANT: NGR-22-009-627
Distribution Limits
Public
Copyright
Other