Cold trap fractionation as an organic analysis technique.

A highly simplified, alternate approach to the gas chromatograph-mass spectrometer has been developed. In this approach, a low temperature trap replaces the entire GC portion of the combined GC-MS instrument and no carrier gas is necessary. Using the cold trap technique, the sample is first passed into a chilled trap. Depending on the trap temperature, many compounds are condensed or trapped out (most at -196 C). Those which are not, such as helium, neon, and nitrogen, pass through the trap directly into the spectrometer for analysis. Then the trap is programmed to increase in temperature at an appropriate rate. This allows evaporation (or sublimation) of the trapped materials according to the specific vapor pressure characteristics of the compound, providing some temporal separation between constituents. These partially resolved components are directed to the MS as they evolve from the trap.