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Biological activity of ionene polymersIonene polymers are polyammonium salts with positive nitrogens in the backbone, resulting from the polycondensation of diamines with dihalides or from the polycondensation of halo amines. The mechanism of formation of ionene polymers of different structures and their biological activity is reviewed. The antimicrobial and antifungal properties are compared with low molecular weight ammonium salts. Ionenes were found to combine with DNA by means of ionic bonds to yield similar complexes to those obtained with polyamines (spermine and spermidine). They also combine with nerve cell receptors and exercise a more powerful and longer duration ganglionic blocking action than their monomeric analogs. The antiheparin activity of ionenes and the thromboresistance of elastomeric ionene heparin coatings is described. The enhanced biological activity of ionenes as compared with low molecular weight compounds is attributed to a cooperative effect of a large number of positive charges on the polymeric chains.
Document ID
19740039368
Acquisition Source
Legacy CDMS
Document Type
Conference Proceedings
Authors
Rembaum, A.
(California Institute of Technology, Jet Propulsion Laboratory, Pasadena Calif., United States)
Date Acquired
August 7, 2013
Publication Date
January 1, 1973
Subject Category
Biosciences
Meeting Information
Meeting: Conference on Polymeric Materials for Unusual Service Conditions
Location: Moffett Field, CA
Start Date: November 29, 1972
End Date: December 1, 1972
Accession Number
74A22118
Funding Number(s)
CONTRACT_GRANT: NAS7-100
Distribution Limits
Public
Copyright
Other

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