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Brain catechol synthesis - Control by brain tyrosine concentrationBrain catechol synthesis was estimated by measuring the rate at which brain dopa levels rose following decarboxylase inhibition. Dopa accumulation was accelerated by tyrosine administration, and decreased by treatments that lowered brain tyrosine concentrations (for example, intraperitoneal tryptophan, leucine, or parachlorophenylalanine). A low dose of phenylalanine elevated brain tyrosine without accelerating dopa synthesis. Our findings raise the possibility that nutritional and endocrine factors might influence brain catecholamine synthesis by controlling the availability of tyrosine.
Document ID
19740052585
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Wurtman, R. J.
Larin, F.
Mostafapour, S.
Fernstrom, J. D.
(MIT Cambridge, Mass., United States)
Date Acquired
August 7, 2013
Publication Date
July 12, 1974
Publication Information
Publication: Science
Volume: 185
Subject Category
Biosciences
Accession Number
74A35335
Funding Number(s)
CONTRACT_GRANT: PHS-AM-11709
CONTRACT_GRANT: NGR-22-009-627
CONTRACT_GRANT: PHS-NS-10459
Distribution Limits
Public
Copyright
Other

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