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Alteration of pituitary-adrenal dynamics induced by a water deprivation regimenExperiments are described which were designed to assess the degree of adaptation that occurs in rats chronically exposed to the stress of a water-deprivation regimen and to determine if that adaptation represents a normalization of the hypothalamic-pituitary-adrenal axis. There were no significant differences in mean corticosterone concentrations among control nondeprived rats 1, 4, and 8 weeks after the start of the experiment. The water-deprived rats, however, had significantly elevated plasma steroids 1 and 4 weeks after the onset of deprivation as compared to controls, but not after 8 weeks. Thus, there was a significant decrease in mean plasma corticosterone levels during water deprivation from 1 week to 8 weeks.
Document ID
19740056165
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Sakellaris, P. C.
Vernikos-Danellis, J.
(NASA Ames Research Center Biomedical Research Div., Moffett Field, Calif., United States)
Date Acquired
August 7, 2013
Publication Date
January 1, 1974
Publication Information
Publication: Physiology and Behavior
Volume: 12
Subject Category
Biosciences
Accession Number
74A38915
Distribution Limits
Public
Copyright
Other

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