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Record Details

Record 81 of 4690
Effect of 14 days of bed rest on urine metabolite excretion and plasma enzyme levels
Author and Affiliation:
Pace, N.
Grunbaum, B. W.
Kodama, A. M.
Rahlmann, D. F.(California, University, Berkeley, Calif., United States)
Newsom, B. D.(NASA Ames Research Center, Moffett Field, Calif., United States)
Abstract: After 1 week of ambulatory base-line measurement, a group of 8 men 19-26 years of age remained continuously recumbent for 14 days. Studies were continued for 1 week following the prolonged recumbency. Urine excretion rates for a number of constituents were determined 2 days before bed rest, on day 14 of bed rest, and day 6 after bed rest. Blood plasma samples were also obtained at these times, and analyzed for several enzymes. On day 14 of bed rest significant increases were observed in urine excretion of total osmotically-active substances, magnesium, calcium, phosphate, creatinine, hydroxyproline, and 17-OH corticosteroids. A decrease occurred in urinary glucose excretion. Plasma levels of alkaline phosphatase and LDH-3 were depressed, while plasma GPT was elevated. Many of these changes persisted on day 6 after bed rest, and are interpreted as concomitants of the disuse atrophy of the musculoskeletal system that characterizes prolonged bed rest and weightlessness.
Publication Date: Jun 01, 1974
Document ID:
19740058251
(Acquired Dec 04, 1995)
Accession Number: 74A41001
Subject Category: BIOSCIENCES
Document Type: Conference Paper
Publisher Information: International Organization
Meeting Information: 17th Plenary Meeting; June 17-July 1, 1974; Sao Paulo; Brazil
Meeting Sponsor: COSPAR
Contract/Grant/Task Num: NGR-05-003-470
Financial Sponsor: NASA; United States
Description: 17p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: BED REST; BLOOD PLASMA; ENZYMES; METABOLIC WASTES; PHYSIOLOGICAL TESTS; URINALYSIS; ATROPHY; MUSCULAR TONUS; MUSCULOSKELETAL SYSTEM; WEIGHTLESSNESS
Imprint And Other Notes: COSPAR, Plenary Meeting, 17th, Sao Paulo, Brazil, June 17-July 1, 1974, Paper. 17 p.
Availability Source: Other Sources
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