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Effect of 14 days of bed rest on urine metabolite excretion and plasma enzyme levelsAfter 1 week of ambulatory base-line measurement, a group of 8 men 19-26 years of age remained continuously recumbent for 14 days. Studies were continued for 1 week following the prolonged recumbency. Urine excretion rates for a number of constituents were determined 2 days before bed rest, on day 14 of bed rest, and day 6 after bed rest. Blood plasma samples were also obtained at these times, and analyzed for several enzymes. On day 14 of bed rest significant increases were observed in urine excretion of total osmotically-active substances, magnesium, calcium, phosphate, creatinine, hydroxyproline, and 17-OH corticosteroids. A decrease occurred in urinary glucose excretion. Plasma levels of alkaline phosphatase and LDH-3 were depressed, while plasma GPT was elevated. Many of these changes persisted on day 6 after bed rest, and are interpreted as concomitants of the disuse atrophy of the musculoskeletal system that characterizes prolonged bed rest and weightlessness.
Document ID
19740058251
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Pace, N.
Grunbaum, B. W.
Kodama, A. M.
Rahlmann, D. F.
(California, University Berkeley, Calif., United States)
Newsom, B. D.
(NASA Ames Research Center Moffett Field, Calif., United States)
Date Acquired
August 7, 2013
Publication Date
June 1, 1974
Subject Category
Biosciences
Meeting Information
Meeting: Plenary Meeting
Location: Sao Paulo
Country: Brazil
Start Date: June 17, 1974
End Date: July 1, 1974
Sponsors: COSPAR
Accession Number
74A41001
Funding Number(s)
CONTRACT_GRANT: NGR-05-003-470
Distribution Limits
Public
Copyright
Other

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