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The effect of synthetic homopolymer poly I:C on the synthesis of nucleic acids, protein and interferon in spleen cells normally and with radiationA comparative study is reported of the effect of the synthetic homopolymer poly I:C and Newcastle Disease virus on the synthesis of RNA, DNA, total protein and interferon in the spleen of nonradiated and radiated mice. In radiated animals, poly I:C and NDV had no stimulating effect on the synthesis of RNA; administration of both inducers to radiated mice did not significantly affect the content of lymphoid cellular elements in the spleen. However, while reduction of RNA synthesis, caused by radiation, also increases slightly under the effect of poly I:C and the virus, the synthesis of interferon in spleen cells and in the entire body is activated.
Document ID
Acquisition Source
Legacy CDMS
Document Type
Antropova, Y. N.
(NASA Headquarters Washington, DC United States)
Konstantinova, I. V.
(NASA Headquarters Washington, DC United States)
Fuks, B. B.
(NASA Headquarters Washington, DC United States)
Talosh, M. Y.
(NASA Headquarters Washington, DC United States)
Veysfeyler, Y. K.
(NASA Headquarters Washington, DC United States)
Date Acquired
August 8, 2013
Publication Date
January 1, 1974
Publication Information
Publication: The Function of the Body and Factors of Space Flight (NASA-TT-C-15971)
Subject Category
Aerospace Medicine
Accession Number
Distribution Limits
Work of the US Gov. Public Use Permitted.

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