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Circadian variation of intercompartmental potassium fluxes in manCircadian rhythms of plasma potassium concentration and urinary potassium excretion persisted in three normal volunteers when diurnal variations in activity, posture, and dietary intake were eliminated for 3-10 days. Measurements of the arteriovenous difference in plasma potassium concentration across the resting forearm and of erythrocyte potassium concentration suggested that there is a net flux of potassium from ICF to ECF in the early morning and a reverse net flux later in the day. The total net ICF-ECF fluxes were estimated from the diurnal variations in extracellular potassium content corrected for dietary intake and urinary potassium loss. The net fluxes between ICF and ECF were found to be counterbalanced by the circadian rhythm in urinary potassium excretion. Desynchronization of these rhythms would result in marked fluctuations in extracellular potassium content. These findings suggest that some revision is required of the concept of basal state in potassium homeostasis.
Document ID
19750037501
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Moore Ede, M. C.
Brennan, M. F.
Ball, M. R.
(Harvard University; Peter Benet Brigham Hospital, Boston, Mass., United States)
Date Acquired
August 8, 2013
Publication Date
January 1, 1975
Publication Information
Publication: Journal of Applied Physiology
Volume: 38
Subject Category
Aerospace Medicine
Accession Number
75A21573
Funding Number(s)
CONTRACT_GRANT: NIH-HL-13872-15
CONTRACT_GRANT: DA-49-193-MD-2337
CONTRACT_GRANT: NAS9-14249
Distribution Limits
Public
Copyright
Other

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