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Regulation of body mass in rats exposed to chronic accelerationFemale rats approximately 6 mo old were chronically centrifuged for up to 30 days at 2.76 G or 3.18 G and sacrificed at intervals for body-composition study. Both fat and the fat-free body mass (FFBM) were reduced during the 1st wk of centrifugation, with the fat showing considerably more variation both within and between groups. The FFBM was reduced below control level to the same extent in rats fed commercial chow, a high-fat diet, or a high-protein diet or in rats prefasted to produce a body-mass deficit at the start of centrifugation. There were no centrifugation-associated changes in body water content. It was concluded that body fat showed no evidence of regulation, FFBM is regulated at any constant level of acceleration between 1 and 4.15 G, and the change in FFBM induced by a change in acceleration is probably not regulated.
Document ID
19750042475
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Pitts, G. C.
Bull, L. S.
Oyama, J.
(Virginia, University, Charlottesville, Va.; NASA, Ames Research Center Environmental Biology Div., Moffett Field, Calif., United States)
Date Acquired
August 8, 2013
Publication Date
March 1, 1975
Publication Information
Publication: American Journal of Physiology
Volume: 228
Subject Category
Life Sciences (General)
Accession Number
75A26547
Funding Number(s)
CONTRACT_GRANT: NGR-47-005-213
CONTRACT_GRANT: NAS2-1554
Distribution Limits
Public
Copyright
Other

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