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Effects of a 2X gravity environment on the ultrastructure of the gerbil parathyroid glandA number of studies concerning the effects of hypergravity on bone have shown increases in bone mass or bone dimensions. Correlative studies, which could provide clues to the mechanism for such a response, have been lacking. The purpose of the present study was to evaluate the ultrastructure of parathyroid glands of Mongolian gerbils exposed to a continuous 2 X gravity force for 60 d. It was found that the experimental animals had parathyroid glands which had a greater percentage of chief cells in the active stage of their secretory cycle when compared with control animals. This result was interpreted to indicate an increase in parathyroid gland secretory activity and, hence, an increase in parathyroid hormone release. It was suggested that increased parathyroid secretory activity was necessary to maintain serum calcium levels of hypergravity animals within normal limits. Cellular forms resembling water clear cells and highly compact, degenerating cells were described in experimental animals but not in controls. Areas suggestive of cellular dissolution and disorganization were also reported in experimental parathyroids.
Document ID
19750050307
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Sannes, P. L.
Hayes, T. G.
(Ohio State University Columbus, Ohio, United States)
Date Acquired
August 8, 2013
Publication Date
June 1, 1975
Subject Category
Life Sciences (General)
Accession Number
75A34379
Funding Number(s)
CONTRACT_GRANT: NAS2-6634
Distribution Limits
Public
Copyright
Other

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