Postmission plasma volume and red-cell mass changes in the crews of the first two Skylab missions

Red-cell mass determinations were performed before and after the first two Skylab missions. The data showed a 14% mean decrease in red-cell mass after the 28-day mission and a 12% mean decrease after the 59-day mission. The red-cell mass returned to premission levels more slowly after the shorter (28-day) than after the longer mission. Plasma volume decreases were found after each mission, with the crew from the longer mission showing the greater change (13% vs 8.4%). Postmission decreases in red-cell mass and plasma volume have been a general finding in crewmen who return from short or long spaceflight.