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Effect of parathyroidectomy on bone growth and composition in the young ratIn an effort to determine the influence of the parathyroids on bone growth and composition, 28-day-old male Sprague-Dawley rats were sacrificed 28, 56, and 84 days after parathyroidectomy or sham parathyroidectomy. Body growth as well as femur growth were retarded following parathyroidectomy. Hypocalcemia and hyperphosphatemia occurred in all parathyroidectomized rats; no alterations in plasma magnesium levels were noted. Femur magnesium was increased by 22-30% in the parathyroidectomized rats whereas femur calcium remained unchanged. Bone phosphorus was increased 56 and 84 days following parathyroidectomy. Results of this study indicate that parathyroidectomy retards growth while increasing bone magnesium and phosphorus content.
Document ID
19750054925
Document Type
Reprint (Version printed in journal)
Authors
Keil, L. C.
Prinz, J. A. (NASA Ames Research Center Moffett Field, Calif., United States)
Evans, J. W. (NASA Ames Research Center Moffett Field; California, University, Davis, Calif., United States)
Date Acquired
August 8, 2013
Publication Date
January 1, 1974
Publication Information
Publication: Growth
Volume: 38
Subject Category
LIFE SCIENCES (GENERAL)
Distribution Limits
Public
Copyright
Other